genetics Archives - MY GENETIC MEDS

What types of heart disease are hereditary?

Ken — Mon, 08 Mar 2021 20:06:55 +0000

We are striving to identify genetic diseases and slow their progression through preventative care and advanced treatment for patients. Here are a few things to consider when deciding to get your own genetic tests.

Is heart disease inherited from mother or father?

One copy is inherited from your mother and one copy is inherited from your father. Genetic conditions are caused by a change (or mutation) in one or more genes passed from generation to generation. Most genetic heart conditions are inherited in an autosomal dominant pattern.

Here are 3 common heart diseases that can be inherited from one generation to the next.
…
Here are 3 common heart diseases that can be inherited from one generation to the next.

All in the Family:

Familial Hypertrophic Cardiomyopathy. …
Familial Dilated Cardiomyopathy. …
Familial Hypercholesterolemia.

What is considered a family history of heart disease?

A family history of heart disease is generally defined by having a first-degree male relative (i.e., father or brother) who had a heart attack by age 55, or a first-degree female relative (i.e., mother or sister) by age 65. Just as important, consider lifestyle changes that improve your heart health

What percentage of heart disease is hereditary?

Heritability includes a combination of genetic factors and the effects of a shared environment such as the types of foods that are served in a family. Only a small percentage of the United States population – 8 percent — has ideal levels of all the risk factors for cardiovascular health at middle age.

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Whats in the PGx Test Results

Ken — Mon, 01 Feb 2021 06:10:57 +0000

What's in the PGx test results and why do you want it?

1. Current Medications and Medications of Interest
Clinical interpretation for patient's current medications provided by physician. This section includes
pharmacogenomics and drug interactions (drug-drug, drug-food, drug-alcohol, drug-lab).

2. Comprehensive Drug List
Includes gene-drug interactions for a 62 gene panel and approximately 100 medications aligned with the latest
FDA pharmacogenetic recommendations and over 150 more arranged by therapeutic area, drug class, and mechanism
of action. This section is designed to help optimize treatment options and manage patients with multiple conditions,
effectively and efﬁciently.

3. Genotype and Phenotype Results
This section will have the patient speciﬁc gene, genotype, and phenotype information of all 62 genes analyzed
in the panel.

Gene-Drug Interaction Types:

Consider Alternative: Refers to gene-drug pairs in which the interaction between a drug and one or several
genes may result in a clinically severe and potentially deadly adverse drug reaction(s) and lack of efﬁcacy.
Most medications included in this gene—drug pair category still can be used. However, please exercise
extreme caution and clinical judgment, read the corresponding gene-drug interaction for your patient, and
follow FDA recommendations.
Use With Caution: Refers to gene-drug pairs in which the interaction between a drug and one or several
genes may result in a mild adverse drug reaction(s) and lack of efﬁcacy. Most medications included in this
gene-drug pair category still can be used. However, please exercise caution and clinical judgment, read the
corresponding gene-drug interaction for your patient, and follow FDA recommendations.

Drug Management: Refers to gene-drug pairs in which a negative drug response (adverse drug reaction(s)
and lack of efﬁcacy) might be preventable by adjusting the medication to the patient's individual needs based
on pharmacogenomic results and any other non-genetic factors of your knowledge. Please exercise caution
and clinical judgment, read the corresponding gene-drug interaction for your patient, and follow FDA
recommendations.
Normal Response Expected: Refers to gene-drug pairs in which the corresponding drug response (adverse
drug reaction(s) risk and efficacy) shall correlate with the FDA label description and is like that of the general
population. Keep in mind that all drugs come with associated risks and should be taken into consideration
when prescribing any medication. Please exercise caution and clinical judgment, read the corresponding
gene-drug interaction for your patient, and follow FDA recommendations.

Functional Phenotype: refers to the proteins function level coded by its gene linked to the individual's
particular genotype. The functional phenotype nomenclature is directly related to the type of function carried
out by the protein following standard cell biology nomenclature.

Patient Impact: Refers to the drug speciﬁc type of clinical outcome as a result of the interaction between a
medication and the protein(s) with which it interacts based on the patient's individual genotype.
Pharmacogenomics (PGx) results DO NOT REPRESENT MEDICAL ADVICE and they SHOULD NOT replace standard protocol—based
pharmacological care. PGx testing provides additional information regarding drug response based on the patient's
genetic make-up associated with pharmacokinetics, pharmacodynamics, and other biological processes with the intent
to provide insights regarding medications efﬁcacy and adverse drug reactions.
ONLY a patient's healthcare provider can make decisions regarding medication selections, medication
dosage, medication additions, medication replacements, and stopping medications.

Note to Patient: While these are your results, YOU should not make any changes to your
medications, unless directly instructed by your healthcare provider.

This is educational information and not meant to entice or persuade a person to follow through with genetic testing.

Edited by Ken Taylor, Owner of My Genetic Meds

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My Genetic Meds In The News!

Ken — Thu, 02 Jan 2020 18:12:12 +0000

I’m 49 years old and live in a town outside of Phoenix, AZ called Santan Valley. I am a caregiver to my wife Barby (yes, we are Ken and Barby). Barby is diagnosed with an autoimmune condition called RSD/CRPS. But if you know how the autoimmune system works, you will understand that often there is more than one diagnosis.

The most challenging part is knowing that you don’t have all the answers. In the beginning, I felt so helpless knowing I could do nothing to stop or even lessen the fire burning pain she was experiencing. Not being able to help felt like I was turning my back and ignoring the situation and took some time to understand how to accept the situation.

Tools and treatments are always advancing, and if you know how and where to find them, there is good reason to be excited about the future for healthcare. The downside is that many of these tools and treatments are not covered by insurance; however, one of the greatest tools I have recently been educated on is covered by your insurance with no out of pocket cost to you regardless of how much your insurance covers. Pharmacogenomics (PGx) combines the study of genetics with the science of drug delivery. PGx DNA testing utilizes next-generation sequencing to optimize medications based on your genetics. This is called Precision Medicine.

Read the whole article at http://voyagephoenix.com/interview/community-highlights-meet-ken-taylor-genetic-meds/

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